Maintenance Therapy for Acute Myelogenous Leukaemia

Ovarian sarcoma and acute myelogenous leukaemia.

VP 16-213 in acute myelogenous leukaemia.

The use of the epipodophyllotoxin VP 16-213 is described in twenty patients with acute myelogenous leukaemia resistant to other chemotherapy. The drug was usually given in 5-day courses of 50 mg/M2 daily and occasionally in 24-hr infusions of 250 mg/M2, on the basis of its phase-activity. Complete remission was achieved in only two patients: in one of these, remission was maintained with VP 16-...

Acute Transformation In Chronic Myelogenous Leukaemia

Fifty-three patients with chronic myeloid leukaemia (CML) were included in this study (25 females & 28 males) and followed-up from October 2003 till October 2005 included for the evidence of acute transformation. Twenty-one patients (39.6%) transformed to acute phase , 16 patients(76.1%) of them transformed during the first 4 years of diagnosis. Fifteen patients (71.4 %) ) transformed to acute ...

Acute myelogenous leukaemia in Hurler's syndrome.

The occurrence of the Hurler syndrome and acute myelogenous leukaemia in a 2 1/2-year-old girl is described. This represents the first published report of the concurrence of these two diseases.

Enteropathy complicating maintenance therapy in acute lymphoblastic leukaemia.

Seven patients being treated for acute lymphoblastic leukaemia between March 1976 and March 1981, in accordance with Medical Research Council protocols, developed clinical malabsorption while on maintenance chemotherapy. All of them received weekly methotrexate and 6 of the 7 were given co-trimoxazole. Five patients had folate deficiency. Stopping the anti-leukaemic therapy led to a resolution...